HPV-Associated Oropharyngeal Cancer Tumor Board

HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer

HPV-positive oropharyngeal cancer patients experience significantly lower locoregional recurrence and higher overall survival in comparison with HPV-negative patients, especially among those who received radiation therapy. The goal of the present study is to investigate the molecular mechanisms underlying the differential radiation sensitivity between HPV-negative and HPV-positive head and neck...

Irradiation of HPV-associated oropharyngeal cancer: Is less really more?

HPV-associated Oropharyngeal Cancers--Are They Preventable?

It is not known whether a human papillomavirus (HPV)-induced oropharyngeal precancerous lesion could be identified by screening with a pap test equivalent or whether one even exists. In this issue of the journal (beginning on page 1378), Fakhry and colleagues report their results showing that cytologic evaluation of the oropharynx, although useful in detecting invasive oropharyngeal cancers, ma...

Impact of HPV in Oropharyngeal Cancer

The incidence of oropharyngeal cancers has increased in the western world and Human Papilloma Virus (HPV) has been recognised as a risk factor in the last decades. During the same period the prevalence of HPV in oropharyngeal tumours has increased and HPV has been suggested responsible for the increase. The HPV-positive tumours are today recognized as a distinct subset of head and neck cancers ...

Prognostic implications of HPV in oropharyngeal cancer.

Identification of human papillomavirus (HPV) as the etiologic agent of cervical cancer has led to its identification in other cancers, with oropharyngeal squamous-cell carcinoma the most common of these.1,2 In this issue of the Journal, Ang and colleagues3 report findings from their study (ClinicalTrials.gov number, NCT00047008) that contribute to the growing body of evidence that HPV-positive ...